Technology
Core Technology
Reactions
Core Technology 
 

1.Low Temperature Reactions

Scale-up of low temperature reactions at Synchem

Low temperature technology as one of many enabling core technologies that makes is possible to produce a wide range of speciality building blocks and intermediates, like boronic acid, aldehydes, halogenated products and many others.

Cryogenic equipment available for

Reactions down to -100 oC in up to 3m3 scale.

Lithiation reactions, quench of Grignard reagent etc.

 

2. Coupling Reactions

Selected examples from Synchem’s portfolio of coupling reactions

At Synchem, organometallic chemistry, including organolithium and magnesium compound preparation, is based on our advanced aryl halides expertise, our strengths in catalyst development and our ability to perform coupling reaction with these compounds.

Synchem offers

1.Catalyst screening and optimization

2.Removal of metal residues

3.Ligand synthesis

4.Catalyst preparation

3. Fluorine chemistry

PSDF - A New Fluorinating Agent

The PSDF can efficiently fluorinate with a variety of electrophiles such as simple alkylhalides, aldehydes and ketones, imines, and cyclic sulfates and sulfamidates to give corresponding substitution or addition products in good to excellent yields.

PSDF is

highly temperature stable

non-toxic

allows reaction of various substrates 

 

4. Asymmetric Hydrogenation

Single enantiomer intermediates of high enantiomeric purity are increasingly required by the pharmaceutical industry. With the increasing availability of high performance asymmetric ligands and technologies fordirectly accessing single enantiomers, catalysis offers a powerful route for economic production.

Synchem’s ligand-Ru catalyst

Reduction of carbonyl compounds using Noyori type catalysts

Key to success

Simple one-pot catalyst system yielding high enantiometic excesses

Inexpensive commercial sources

 

 

 

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